When administering Diphenhydramine for anaphylaxis, what volume of saline should it be diluted with?

When administering Diphenhydramine for the treatment of anaphylaxis, it is important to consider the appropriate volume for dilution to ensure safe and effective delivery of the medication. The proper dilution allows for easier administration, particularly via intravenous (IV) route, ensuring the medication can be given in a manner that is safe and can be monitored effectively.

Diluting Diphenhydramine in a larger volume like 50mL of 0.9% saline helps facilitate easier IV administration and reduces the risk of local irritation at the injection site, which could occur with concentrated solutions. This volume is also more aligned with standard protocols in emergency care, where larger volumes are common for IV medications to ensure proper mixing and delivery.

The choice of 50mL provides a balance between effective administration and maintaining the integrity of the patient's venous access, as it allows for thorough flushing of the line post-administration, ensuring the patient receives the full dose of the medication while also minimizing potential complications associated with IV therapy.